061 ALTERED SCLEROSTIN SYNTHESIS IN CARTILAGE AND BONE CONTRIBUTE OA PATHOLOGY

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

OBJECTIVE Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway upon OA-associated pathologies such as osteophyte formation and pain is unknown. Herein, we investigated early temporal bone and cartilage changes in experimental OA in order to further elucidate the role of PAR2 in OA pathogene...

Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism.

Altered function in cartilage derived mesenchymal stem cell leads to OA-related cartilage erosion.

A portion of osteoarthritis (OA) patients with total knee arthroplasty (TKA) had monocondylar destruction in medial femoral condyle, but healthy-appearant cartilage in lateral side. However, there is limited information concerning functional differences of cartilage derived mesenchymal stem cell (CMSC) between these two locations in the same donor and its possible role in the pathogenesis of OA...

In Situ Measurement of Transport between Subchondral Bone and Cartilage: A Potential Factor in OA Development

Introduction Osteoarthritis (OA) is related to changes not only in articular cartilage but also in bone, ligament, synovium, and muscle. There is increasing evidence from OA patients and animal models that subchondral bone turnover is increased and may play a significant role in the initiation and/or progression. Specifically, it was proposed that the cytokines and growth factors released durin...

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

INTRODUCTION Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and cartilage in a joint instability model in mice. METHODS Ten-week-old SOST-knockout (SOST-KO) and wild-type (WT) mice underwent destabilization of the medial meniscus (DMM)....